Layer Chromatography Questions


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Protonated/Deprotonated Drug – General Understanding I have a general problem in my understanding of protonated and deprotonated drugs and the role of pka. Generally, a low pka indicted a strong acid. When pka = pH we can expect to have a drug 50% protonated and 50% deprotonated. However, when we go two unites above or below the pka value of a drug, then we can expect 99% of it to be undissociated and 1% dissociated. For an acid it would imply that if: pH < pka -> the protonated form exists predominately When we have pH > pKa -> the deprotonated form dominates. This now where I struggle when I try to apply these principles in practice. From what pka range can I start classyfing drugs into “Basic” and acidic? Is a pka 10 and above considered a basic drug? Lets take Paracetamol as an example. It has a pka value of 9,4, which I would interpret

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