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Answer the following questions using the study from the NEJM provided. 1. Describe the extended Glasgow outcome scale (GOSE)? [4] 2. The investigators used the GOSE tool as their key outcome measure in this study – list two limitations in their approach. [2] 3. List the key selection criteria for this trial. [6] 9. a) b) c) What is blinding in a study? [1] What level of blinding was used in this study? [1] What is a potential risk of the approach taken by the investigators? [1] 10. List three issues around the consenting process this study. [3] 11. List four potential ethical considerations in planning this study. [4] 12. Give two benefits and two limitations of having a multicentre study. [4] 13. a) What is bias?

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